MEDICATIONS CONTRAINDICATED IN PREGNANCY

-
1. Vitamin A and its derivatives (isotretinein, Accutane and etretinate)Women who are pregnant should not take regular vitamins. Too many vitamins can harm your baby. For example, very high levels of vitamin A have been linked with severe birth defects.Significant risk of spontaneous abortion [20] and risk of many significant anomalies2. ACE inhibitors (May cause fetal hypotension, kidney damage in the fetus when used in II and III trimester, decrease in the amount of amniotic fluid and deformities of face, limbs and lungs)3. Anticoagulants- warfarinDuring 1st Trimester- defects like nasal hypoplasia and a depressed nasal bridge; termed as Fetal warfarin SyndromeDuring 2nd and 3rd Trimester- risk of fetal malformations
4. Anti-thyroids (Methimazole, Carbimazole) - Overactive and enlarged Thyroid gland.
5. Anticonvulsants- Carbamazepine (Risk of birth defects)
                                 Sodium valproate (Increased risk cleft palate and abnormalities of the heart, face, skull, hands or abdominal organs)6. NSAIDs     Aspirin and other Salicylates  Delay in start of labor, premature closing of ductus arteriosus, jaundice, brain damage in the fetus and bleeding problems in the woman during and after delivery and in the newbornCan cause serious blood flow problems in the baby if used during the last 3 months of pregnancy7. Ciprofloxacin          Possibility of joint abnormalities8. Kanamycin and Streptomycin        Damage to fetus's ear resulting in deafness (risk of ototoxicity9. Oral Hypoglycemic drugs   A very low level of sugar in the blood of newborn.


Subscribe to Drugs Information Center by Email

Comments

Post a Comment

Popular posts from this blog

Treatment Guidelines for Malaria Contd...

-
Treatment regimens for uncomplicated malaria in adults _ Oral quinine sulphate 600 mg/8 h for 5e7 days plus doxycycline 200 mg daily (or clindamycin 450 mg/8 h for pregnant women) for 7 days _ Atovaquoneeproguanil (Malarone_): 4 ‘standard’ tablets daily for 3 days or _ Co-artem ((artemetherelumefantrine_): if weight > 35 kg, 4 tablets  then 4 tablets at 8, 24, 36, 48 and 60 h   Child Initial dose 10 mg/kg/base then 5 mg/kg  base 6e8 h later and on days 2 and 3   However, both of these newer regimens need to be taken for only 3 days. In contrast, quinine needs to be taken for 5e7 days and is often associated with ‘‘cinchonism’’ (nausea, deafness and ringing in the ears), which often results in poor adherence. Although international recommendations suggest that quinine should be  taken for 7 days in endemic areas, 2  UK experience suggests  that 5 days treatment is adequate for the vast majority of cases. Quinine should be combined with a second drug (doxycycline for adults or clindam
Read more

“Gatifloxacin can cause severe hyperglycemia”

-
A 65-year-old woman with no history of diabetes, developed hyperglycemia, after taking Gatifloxacin. She was admitted to the hospital with a one day history of abdominal cramps, nausea, and vomiting. Her blood glucose was 1,121 mg/dL (normal range 70 to 100 mg/ dL). She had a history of high BP, transient ischemic attacks, hyperlipidemia and renal failure. The patient was receiving Gatifloxacin 200 mg daily for 9 days empirically for bronchitis, which was started during a prior hospitalization. After admission, she responded well to an insulin infusion combined with subcutaneous doses of regular insulin. (Ann Pharmacother. 2005; 39(7):1349–1352) Reports of hypoglycemia with other fluoroquinolones have been documented, but only Gatifloxacin is reported to cause severe hyperglycemia Subscribe to Drugs Information Center by Email
Read more

EFFECT OF ACETAMINOPHEN ON BLOOD PRESSURE

-
Acetaminophen produces its analgesic effect by inhibiting the same cyclooxygenase, prostaglandin H2 synthase, that is the target of NSAID and aspirin. However, acetaminophen blocks this enzyme at its peroxidase catalytic rather than at the cyclooxygenase catalytic site. Therefore, the acetaminophen-mediated inhibition is sensitive to changes in the tissue peroxide levels; higher concentrations of peroxide in activated leukocytes and platelets block the effect of acetaminophen on inflammation and platelet thrombosis. However, acetaminophen is able to inhibit prostaglandins in the central nervous system, thus providing relief of pain and fever. Therefore, acetaminophen is not an NSAID or anti-thrombotic agent.   Subscribe to Drugs Information Center by Email
Read more