Drugs Information Center(DIC)

Grapefruit juice can decrease the absorption of fexofenadine from the stomach into the bloodstream. This could make fexofenadine less effective. To avoid this interaction, take fexofenadine with water or liquids other than fruit juices. Do not take fexofenadine with grapefruit juice or grapefruit itself. Also avoid taking fexofenadine with apple juice and orange juice.Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems. Subscribe to Drugs Information Center by Email

Clinical Use :Ø ART experienced patients with CCR5 tropic HIV-1 virus and withdetectable viral resistance to multiple ARTs Ø Should not be used in treatment naïve patient Failure :• Tropism for conversion from CCR 5 to CXCR 4 or dual or mixedtropism of HIV-1 • v3 loop mutation in gp120 Recommended Maraviroc Dose :1) 150mg oral BD in combination with CYP3A inhibitors (proteaseinhibitors,azole itraconazol/ ketoconazol, clarithromycin).2) 300mg oral BD in combination with ritonavir boosted tipranavir, NRTI,enfuvirtide, nevirapine or other drugs without CYP3A effect.3) 600mg oral BD with CYP 3A inducers efavirenz, entravirin, rifampicin,st. jone`s wart.Metabolism :Primarily by liverToxicities: Diarrhoea, nausea, fatigue, headache and derangement ofliver function testVicriviroc:Plasma half life markedly increased by CYP 3A4 inhibitorsPlasma half life >24 hrsNo food effectDurable antiretroviral activity in CCR5 tropic strainUnder Phase III trialAlpraviroc: Hepatotoxic, so trial was termin