Ultram

Ultram is the Generic form of Ultram. ULTRAN ® (tranadol hydrochloride tablets) is a prescription medication indicated for the management of moderate to moderately severe pain. ULTRAM received U.S. Food and Drug Administration (FDA) approval in March, 1995. Ultram has been prescribed to more than 55 million patients worldwide and ULTRAM has been prescribed to more than 21 million patients in the United States alone.

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Tenecteplase versus Alteplase for Acute Ischemic Stroke

Intravenous alteplase is the only approved treatment for acute ischemic stroke. Tenecteplase, a genetically engineered mutant tissue plasminogen activator, is an alternative thrombolytic agent.
Tenecteplase was associated with significantly better reperfusion and clinical outcomes than alteplase in patients with stroke who were selected on the basis of CT perfusion imaging.

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“Gatifloxacin can cause severe hyperglycemia”

A 65-year-old woman with no history of diabetes, developed hyperglycemia, after taking Gatifloxacin. She was admitted to the hospital with a one day history of abdominal cramps, nausea, and vomiting. Her blood glucose was 1,121 mg/dL (normal range 70 to 100 mg/ dL). She had a history of high BP, transient ischemic attacks, hyperlipidemia and renal failure. The patient was receiving Gatifloxacin 200 mg daily for 9 days empirically for bronchitis, which was started during a prior hospitalization. After admission, she responded well to an insulin infusion combined with subcutaneous doses of regular insulin. (Ann Pharmacother.2005; 39(7):1349–1352)

Reports of hypoglycemia with other fluoroquinolones have been documented, but only Gatifloxacin is reported to cause severe hyperglycemia

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Omeprazole+ Sodium bicarbonate

FDA Approved OTC Version Of Heartburn Drug Zegerid (omeprazole and sodium bicarbonate) on December 2, 2009.

Omeprazole is sensitive to acidic environment, so it is destroyed partly is stomach. Sodium bicarbonate saves it from destruction and increases the bioavailability by its acid neutralisation capacity.

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