Drugs List


MEDICATIONS CONTRAINDICATED IN PREGNANCY

1. Vitamin A and its derivatives (isotretinein, Accutane and etretinate)Women who are pregnant should not take regular vitamins. Too many vitamins can harm your baby. For example, very high levels of vitamin A have been linked with severe birth defects.Significant risk of spontaneous abortion [20] and risk of many significant anomalies2. ACE inhibitors (May cause fetal hypotension, kidney damage in the fetus when used in II and III trimester, decrease in the amount of amniotic fluid and deformities of face, limbs and lungs)3. Anticoagulants- warfarinDuring 1st Trimester- defects like nasal hypoplasia and a depressed nasal bridge; termed as Fetal warfarin SyndromeDuring 2nd and 3rd Trimester- risk of fetal malformations
4. Anti-thyroids (Methimazole, Carbimazole) - Overactive and enlarged Thyroid gland.
5. Anticonvulsants- Carbamazepine (Risk of birth defects)
                                 Sodium valproate (Increased risk cleft palate and abnormalities of the heart, face, skull, hands or abdominal organs)6. NSAIDs     Aspirin and other Salicylates  Delay in start of labor, premature closing of ductus arteriosus, jaundice, brain damage in the fetus and bleeding problems in the woman during and after delivery and in the newbornCan cause serious blood flow problems in the baby if used during the last 3 months of pregnancy7. Ciprofloxacin          Possibility of joint abnormalities8. Kanamycin and Streptomycin        Damage to fetus's ear resulting in deafness (risk of ototoxicity9. Oral Hypoglycemic drugs   A very low level of sugar in the blood of newborn.


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Basics of Oral Anti-diabetic drugs

The sulfonylureas and meglitinides increase the secretion of insulin by the pancreas.
_ Metformin inhibits glucose production by the liver and decreases insulin resistance.
_ The alpha-glucosidase inhibitors delay absorption of glucose by the intestine.
_ The thiazolidinediones decrease insulin resistance.

_ The dipeptidyl peptidase 4 inhibitors promote the release of insulin from the pancreas after eating a meal.

It is necessary to know before starting these drugs that all the diabetes drugs have the potential to cause side effects and lifestyle changes have benefits to your health beyond controlling blood sugar, most doctors will recommend you try diet and lifestyle modifications first — before you try a drug.

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FDA Adds 8 Drugs to Watch List

1. Cetirizine HCl       =========>    Oculogyric crisis
2. Codeine sulfate     =========> Respiratory depression or arrest resulting in death in children taking
                                                       codeine who are CYP2D6 ultra-rapid metabolizers
3. Fluoroquinolone =========> Retinal detachment
4. Olmesartan medoxomil  =========>Malabsorption resulting in severe diarrhea and weight loss      
5. Proton pump inhibitors  =========>Pneumonia            

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EFFECT OF ACETAMINOPHEN ON BLOOD PRESSURE


Acetaminophen produces its analgesic effect by inhibiting the same cyclooxygenase, prostaglandin H2 synthase, that is the target of NSAID and aspirin. However, acetaminophen blocks this enzyme at its peroxidase catalytic rather than at the cyclooxygenase catalytic site. Therefore, the acetaminophen-mediated inhibition is sensitive to changes in the tissue peroxide levels; higher concentrations of peroxide in activated leukocytes and platelets block the effect of acetaminophen on inflammation and platelet thrombosis. However, acetaminophen is able to inhibit prostaglandins in the central nervous system, thus providing relief of pain and fever. Therefore, acetaminophen is not an NSAID or anti-thrombotic agent.
 



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