“Gatifloxacin can cause severe hyperglycemia”

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A 65-year-old woman with no history of diabetes, developed hyperglycemia, after taking Gatifloxacin. She was admitted to the hospital with a one day history of abdominal cramps, nausea, and vomiting. Her blood glucose was 1,121 mg/dL (normal range 70 to 100 mg/ dL). She had a history of high BP, transient ischemic attacks, hyperlipidemia and renal failure. The patient was receiving Gatifloxacin 200 mg daily for 9 days empirically for bronchitis, which was started during a prior hospitalization. After admission, she responded well to an insulin infusion combined with subcutaneous doses of regular insulin. (Ann Pharmacother.2005; 39(7):1349–1352)

Reports of hypoglycemia with other fluoroquinolones have been documented, but only Gatifloxacin is reported to cause severe hyperglycemia


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