Amlodipine and Valsartan

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WARNINGS AND PRECAUTIONS-

  • Avoid use in pregnancy.
  • Fetal/Neonatal Morbidity and Mortality - can cause fetal harm when administered to a pregnant woman. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
    Drugs that act on the renin angiotensin system can cause fetal and neonatal morbidity and mortality when used in pregnancy. In several dozen published cases, ACE inhibitor use during the second and third trimesters of pregnancy was associated with fetal and neonatal injury, including hypotension, neonatal skull hypoplasia, anuria, reversible or irreversible renal failure, and death.
  • Hypotension- Volume depletion should be corrected prior to administration .
  • Impaired Renal Function - Hypertension

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