Drugs Information Center(DIC)

1.  Cetirizine HCl        =========>     Oculogyric crisis 2.  Codeine sulfate       =========>   Respiratory depression or arrest  resulting in death in children taking                                                        codeine who are CYP2D6 ultra-rapid  metabolizers 3.  Fluoroquinolone  =========>  Retinal detachment 4.  Olmesartan  medoxomil    =========> Malabsorption resulting in severe  diarrhea and weight loss        5.  Proton pump  inhibitors    =========> Pneumonia               Subscribe to Drugs Information Center by Email

Acetaminophen produces its analgesic effect by inhibiting the same cyclooxygenase, prostaglandin H2 synthase, that is the target of NSAID and aspirin. However, acetaminophen blocks this enzyme at its peroxidase catalytic rather than at the cyclooxygenase catalytic site. Therefore, the acetaminophen-mediated inhibition is sensitive to changes in the tissue peroxide levels; higher concentrations of peroxide in activated leukocytes and platelets block the effect of acetaminophen on inflammation and platelet thrombosis. However, acetaminophen is able to inhibit prostaglandins in the central nervous system, thus providing relief of pain and fever. Therefore, acetaminophen is not an NSAID or anti-thrombotic agent.   Subscribe to Drugs Information Center by Email

Ultram is the Generic form of Ultram. ULTRAN ® (tranadol hydrochloride  tablets) is a prescription medication indicated for the management of  moderate to moderately severe pain. ULTRAM received U.S. Food and Drug  Administration (FDA) approval in March, 1995. Ultram has been  prescribed to more than 55 million patients worldwide and ULTRAM has  been prescribed to more than 21 million patients in the United States  alone. Subscribe to Drugs Information Center by Email

Intravenous alteplase is the only approved treatment for acute ischemic stroke. Tenecteplase, a genetically engineered mutant tissue plasminogen activator, is an alternative thrombolytic agent. Tenecteplase was associated with significantly better reperfusion and clinical outcomes than alteplase in patients with stroke who were selected on the basis of CT perfusion imaging. Source Subscribe to Drugs Information Center by Email

A 65-year-old woman with no history of diabetes, developed hyperglycemia, after taking Gatifloxacin. She was admitted to the hospital with a one day history of abdominal cramps, nausea, and vomiting. Her blood glucose was 1,121 mg/dL (normal range 70 to 100 mg/ dL). She had a history of high BP, transient ischemic attacks, hyperlipidemia and renal failure. The patient was receiving Gatifloxacin 200 mg daily for 9 days empirically for bronchitis, which was started during a prior hospitalization. After admission, she responded well to an insulin infusion combined with subcutaneous doses of regular insulin. (Ann Pharmacother. 2005; 39(7):1349–1352) Reports of hypoglycemia with other fluoroquinolones have been documented, but only Gatifloxacin is reported to cause severe hyperglycemia Subscribe to Drugs Information Center by Email

FDA Approved OTC Version Of Heartburn Drug Zegerid (omeprazole and sodium bicarbonate) on December 2, 2009. Omeprazole is sensitive to acidic environment, so it is destroyed partly is stomach. Sodium bicarbonate saves it from destruction and increases the bioavailability by its acid neutralisation capacity. Subscribe to Drugs Information Center by Email

Dexmedetomidine is a sedative medication used by intensive care units and anesthesiologists. It is relatively unique in its ability to provide sedation without causing respiratory depression . Like clonidine , its mechanism of action is agonism of alpha-2 receptors in certain parts of the brain. Dexmedetomidine has sedative, analgesic, sympatholytic, and anxiolytic effects that blunt many of the cardiovascular responses in the perioperative period. It reduces the volatile anesthetic, sedative and analgesic requirements of the patient without causing significant respiratory depression. Recent research has suggested dexmedetomidine to be an effective treatment for the dangerous cardiovascular symptoms of cocaine intoxication and overdose . It also seemed to be superior to lorazepam for ventilated patients in the intensive care unit . Compared to midazolam , dexmedetomidine was similarly effective for sedation, but shortened the time to extubation , was associated with less deliriu...