Amantadine
Class of drug: Treatment for Parkinson’s disease, antiviral agent. Mechanism of action: Anti-Parkinson action: promotes release of dopamine in substantia nigra. Antiviral action: prevents viral penetration of influenza A virus into target host cells. Indications/dosage/route: Oral only . Parkinson’s disease Ð Adults: 100 mg b.i.d., may be titrated up. Maximum: 400 mg/d. Influenza A: Ð Adults: 200 mg/d, single or divided dose. Adjustment of dosage: Kidney disease: reduce dose as follows. Creatinine clearance 30–50 mL/min: initial 200 mg, then 100 mg/d; creatinine clearance 15–29 mL/min: initial 200 mg, then 100 mg q.i.d.; creatinine clearance • Liver disease: None • Elderly: Dosage should be divided as twice daily administration. Contraindications: Hypersensitivity to amantadine, untreated angle-closure glaucoma. Warnings/precautions: Use with caution in patients with the following conditions: Psychiatric disorders, liver or kidney disease, history of epilepsy, peripheral edema, ortho...