Adenosine
Class of drug : Antiarrhythmic. Mechanism of action : Vagolytic effect: Slows conduction through AV node; prevents reentry through AV node. Restores normal sinus rhythm in patients with paroxysmal supraventricular tachycardia including Wolff–Parkinson–White syndrome. Indications/dosage/route : IV only. Paroxysmal supraventricular tachycardia Ð Adults: bolus of 6 mg. If no effect after 1–2 min, 12-mg bolus. May repeat 12-mg dose × 2. Adjustment of dosage • Kidney disease: None. Liver disease: None. Elderly: None. Contraindications: Second- or third-degree AV block (without pacemaker), sick sinus syndrome, symptomatic bradycardia. Warnings/precautions Use with caution in patients with the following condition: Stroke, asthma, unstable angina (higher risk of arrythmias, MI). Cardiac arrest (including fatalities), ventricular tachycardia, and MI have been reported coincident with use. May produce transient first-, second-, third-degree AV block. Asystole has been reported in atrial flutter ...