Drugs Information Center(DIC)

Acetaminophen produces its analgesic effect by inhibiting the same cyclooxygenase, prostaglandin H2 synthase, that is the target of NSAID and aspirin. However, acetaminophen blocks this enzyme at its peroxidase catalytic rather than at the cyclooxygenase catalytic site. Therefore, the acetaminophen-mediated inhibition is sensitive to changes in the tissue peroxide levels; higher concentrations of peroxide in activated leukocytes and platelets block the effect of acetaminophen on inflammation and platelet thrombosis. However, acetaminophen is able to inhibit prostaglandins in the central nervous system, thus providing relief of pain and fever. Therefore, acetaminophen is not an NSAID or anti-thrombotic agent.   Subscribe to Drugs Information Center by Email

Advise patient it is unsafe to take more than 4 grams of acetaminophen in a 24-hour period. Instruct patient that many non-prescription combination products may contain acetaminophen. Instruct patient to report signs/symptoms of gastrointestinal hemorrhage, hepatotoxicity, or nephrotoxicity. Patient should take with a full glass of water. Patient should not drink alcohol while taking this drug. Advise patients who drink more than 3 alcoholic drinks a day to consult a healthcare professional prior to taking acetaminophen. Dosing - Adult Dysmenorrhea: 650 to 1000 mg ORALLY every 4 h as needed, maximum 4 g/day Dysmenorrhea: 650 mg RECTALLY every 4 to 6 h; maximum 6 suppositories/24 h Fever: 650 to 1000 mg ORALLY every 4 h as needed, maximum 4 g/day Fever: 650 mg RECTALLY every 4 to 6 h; maximum 6 suppositories/24 h Headache: 650 to 1000 mg ORALLY every 4 h as needed, maximum 4 g/day Headache: 650 mg RECTALLY every 4 to 6 h; maximum 6 suppositories/24 h Pain (Mild to Moderate): 650 to 1000...