Drugs Information Center(DIC)

1.  Cetirizine HCl        =========>     Oculogyric crisis 2.  Codeine sulfate       =========>   Respiratory depression or arrest  resulting in death in children taking                                                        codeine who are CYP2D6 ultra-rapid  metabolizers 3.  Fluoroquinolone  =========>  Retinal detachment 4.  Olmesartan  medoxomil    =========> Malabsorption resulting in severe  diarrhea and weight loss        5.  Proton pump  inhibitors    =========> Pneumonia               Subscribe to Drugs Information Center by Email

Acetaminophen produces its analgesic effect by inhibiting the same cyclooxygenase, prostaglandin H2 synthase, that is the target of NSAID and aspirin. However, acetaminophen blocks this enzyme at its peroxidase catalytic rather than at the cyclooxygenase catalytic site. Therefore, the acetaminophen-mediated inhibition is sensitive to changes in the tissue peroxide levels; higher concentrations of peroxide in activated leukocytes and platelets block the effect of acetaminophen on inflammation and platelet thrombosis. However, acetaminophen is able to inhibit prostaglandins in the central nervous system, thus providing relief of pain and fever. Therefore, acetaminophen is not an NSAID or anti-thrombotic agent.   Subscribe to Drugs Information Center by Email