Drugs Information Center(DIC)

FDA Approved OTC Version Of Heartburn Drug Zegerid (omeprazole and sodium bicarbonate) on December 2, 2009. Omeprazole is sensitive to acidic environment, so it is destroyed partly is stomach. Sodium bicarbonate saves it from destruction and increases the bioavailability by its acid neutralisation capacity. Subscribe to Drugs Information Center by Email

Dexmedetomidine is a sedative medication used by intensive care units and anesthesiologists. It is relatively unique in its ability to provide sedation without causing respiratory depression . Like clonidine , its mechanism of action is agonism of alpha-2 receptors in certain parts of the brain. Dexmedetomidine has sedative, analgesic, sympatholytic, and anxiolytic effects that blunt many of the cardiovascular responses in the perioperative period. It reduces the volatile anesthetic, sedative and analgesic requirements of the patient without causing significant respiratory depression. Recent research has suggested dexmedetomidine to be an effective treatment for the dangerous cardiovascular symptoms of cocaine intoxication and overdose . It also seemed to be superior to lorazepam for ventilated patients in the intensive care unit . Compared to midazolam , dexmedetomidine was similarly effective for sedation, but shortened the time to extubation , was associated with less deliriu...